Antimicrobial Actions of Hexachlorophene: Inhibition of Respiration in Bacillus megaterium

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Antimicrobial actions of hexachlorophene: inhibition of respiration in Bacillus megaterium.

Hexachlorophene (HCP) inhibits both endogenous and exogenous respiration (oxygen uptake) in Bacillus megaterium, without sparing by any of several substrates. The inhibition is maximal when the cells are treated with 8 mug of HCP per mg of cells (dry weight), which corresponds to the minimal lethal dose. Levels as low as 2 mug/mg are inhibitory but not lethal. HCP also inhibits the respiration ...

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Antimicrobial actions of hexachlorophene: lysis and fixation of bacterial protoplasts.

Hexachlorophene was found to be both a lytic and a fixative agent for protoplasts isolated from Bacillus megaterium. Concentrations of 50 to 100 mug of drug per mg of original cell dry weight were required to lyse 4.4 x 10(9) protoplasts (2 mg of original cell dry weight). At higher drug concentrations, protoplasts became fixed against osmotic stress and reduced in sensitivity to disruption by ...

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Plasmolysis in Bacillus Megaterium.

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The stimulation of germination and respiration of Bacillus megaterium spores by mangasese, L-alanine and heat.

Germination of spores of the genus Bacillus can be stimulated by heat, L-alanine, or manganese. The reversal of L-alanine stimulation by D-alanine (Hills, 1950) appears to be specific and, in the present study, affords a tool for the exploration of the mechanisms and interrelations among heat, manganese and L-alanine stimulations. The heat stimulation of bacterial spore germination has long bee...

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The Stimulation of Germination and Respiration of Bacillus Megaterium Spores by Manganese, L-alanine and Heat

Germination of spores of the genus Bacillus can be stimulated by heat, L-alanine, or manganese. The reversal of L-alanine stimulation by D-alanine (Hills, 1950) appears to be specific and, in the present study, affords a tool for the exploration of the mechanisms and interrelations among heat, manganese and L-alanine stimulations. The heat stimulation of bacterial spore germination has long bee...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1974

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.6.6.712